Poziom retikulocytów i trombocytów w krwi obwodowej myszy po wielokrotnym podaniu małych dawek azotanu ołowiowego

Abstract

Research on the level of reticulocytes and trombocytes is the peripheral blood of mice submitted to the action of plumbous nitrate was carried within two experimental series. The first series included 10 mice (5 males and 5 females) to which for seven consecutive days subcutaneous injections of plumbous nitrate - $Pb(NO_3)_2$ were made, the daily dose being 0,2 mg. Animals of the second series, equally ten in number, within fourteen days were given injections of 0,3 mg plumbous nitrate per day. Thus, the first-group mice were administered within 7 days an over-all amount of 1,4 mg each, while the second- group mice within 14 days - 4,2 mg plumbous nitrate each. As a result of these experiments the author has been able to establish that chronic doses of plumbous nitrate bring about a pronounced growth the number of reticulocytes, reticulosis growing with the increase in the dosage of this compound and with the lenghtening of the injection period. A characteristic trait is the continuous growth of their number, even when there was a 7-day interval in the making of injections. A simultaneous decrease in the number of trombocytes was noted, which testifies to the restraining effect exerted by plumbous nitrate upon the trombocyte-formative system.