Możliwości różnicowania in vitro układów złożonych z matrycy polimerowej i substancji czynnej metodą Magnetycznego Rezonansu Jądrowego w kontekście układów farmaceutycznych o kontrolowanym uwalnianiu

Abstract

This article describes possibilities of investigations of systems comprised of polymer and active (drug) substance by means of Magnetic Resonance methods. Such systems are commonly used for preparing prolonged, controlled release dosage forms. Dissolution study is a basic method in pharmaceutical industry for evaluation of dosage forms. Magnetic resonance imaging (MR imaging) can be used as an additional method performed simultaneously with dissolution study in the non-invasive manner. Basics of MR imaging were described shortly together with equipment necessary to obtain MR images. Existing hardware setups for simultaneous MR imaging and dissolution study were presented. Advantages of the setup developed by the authors of the article were emphasized. The method can be directly applied to obtain quantitative information about differences between investigated dosage forms even when the have identical dissolution profiles. Literature data showed that dosage forms having identical dissolution profiles can have different bioavailability.